Liverpool make five changes from the side that lost away to Galatasaray in the Champions League – but the stand out selection is Mohamed Salah, substituted in Turkey, being dropped to the bench.
Rio Ngumoah, just 17, starts his first Premier League game, while Alisson is back in goal in place of Giorgi Mamardashvili after missing out in midweek through injury.
Ibramhima Konate is also left out after a poor performance in midweek, while Andrew Robertson comes in for Milos Kerkez.
Liverpool XI: Alisson, Gomez, Van Dijk, Wirtz, Szoboszlai, Mac Allister, Gakpo, Robertson, Frimpong, Gravenberch, Ngumoha.
Subs: Mamardashvili, Konate, Kerkez, Salah, Chiesa, Jones, Ekitike, Nyoni, Ramsay.
Spurs interim head coach Igor Tudor is without 13 players through injury and suspension as he tries to ease growing relegation worries at Liverpool.
The Croatian makes four changes from the side thrashed 5-2 away to Atletico Madrid in the Champions League, but is only able to name seven substitutes, including two keepers.
Guglielmo Vicario returns in goal for Antonin Kinsky, substituted after only 17 minutes in the Madrid debacle.
Captain Cristian Romero is out with concussion suffered in Madrid, while Micky van de Ven is out suspended after his sending off against Crystal Palace.
Radu Dragusin and Souza come in, while Dominic Solanke replaced Randal Kolo Muani.
Tottenham XI: Vicario; Porro, Dragusin, Danso; Spence, Gray, Sarr, Souza; Richarlison, Solanke, Tel.
Subs: Kinsky, Austin, Simons, Kolo Muani, Olusesi, Roswell, Wilson.
