Celtic will face Dundee, and holders Aberdeen welcome Motherwell, in the only two all-Premiership ties in the last 16 of this season's Scottish Cup.
Rangers will host the winner of Tuesday's meeting of Stranraer and Queen's Park, Dundee United will welcome League 2 leaders The Spartans, St Mirren visit Championship side Airdrieonians and Falkirk have a derby with League 1 pacesetters Stenhousemuir.
There will be another derby between Dunfermline Athletic and Fife rivals Kelty Hearts and League 2 Elgin City will host Partick Thistle.
The ties will be played on the weekend of February 7/8.
