Tammy Abraham starts ahead of Ollie Watkins as Aston Villa look to reach the Europa League quarter-finals.
Victor Lindelof also makes his first start for over a month in defence with boss Unai Emery making six changes from Sunday's defeat at Manchester United.
Jadon Sancho, Ian Maatsen, Pau Torres and Douglas Luiz return.
Aston Villa XI: Martinez, Bogarde, Lindelof, Torres, Maatsen, Luiz, Onana, McGinn, Rogers, Sancho, Abraham.
Subs: Bizot, Wright, Mings, Konsa, Digne Cash, Garcia, Elliott, Buendia, Bailey, Watkins.
Former Arsenal striker Olivier Giroud starts for Lille as they look to overcome their first-leg deficit.
Ex-Tottenham and Newcastle midfielder Nabil Bentaleb is also in for the French side, who are fifth in Ligue 1.
Lille XI: Ozer, Ngoy, Alexsandro, Mbemba, Perraud, Bouaddi, Bentalab, Mukau, Meunier, Giroud, Correia.
Subs: Bodart, Lanssade, Fernandez-Pardo, Haraldsson, Edjouma, Tiago Santos, Mandi, Verdonk, Diaoune, Baret, Boussadia.
