Ben White comes in to start for Arsenal for the injured Jurrien Timber. Piero Hincapie replaces Riccardo Calafiori and Viktor Gyokeres starts as the Gunners striker. After his record-breaking goal against Everton on Sunday, 16-year-old Max Dowman is on the bench.
Leandro Trossard returns from the hip complaint that ruled him out at the weekend, with Noni Madueke dropping to the bench, while Viktor Gyokeres leads the line up front.
Arsenal starting XI: Raya, White, Saliba, Gabriel, Hincapie, Rice, Zubimendi, Eze, Saka, Trossard, Gyokeres
Subs: Arrizabalaga, Ranson, Mosquera, Jesus, Martinelli, Norgaard, Madueke, Havertz, Calafiori, Lewis-Skelly, Dowman
Kasper Hjulmand names the same Bayer Leverkusen side that drew with Arsenal in the first leg.
Leverkusen starting XI: Blaswich, Quansah, Andrich, Tapsoba, Poku, Grimaldo, Garcia, Palacios, Maza, Terrier, Kofane
Subs: Omlin, Lomb, Fernandez, Hofmann, Tillman, Schick, Oermann, Tape, Culbreath
