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May 14, 2026, 08:20 PM ETOpen Extended Reactions
The complete 2026 NFL schedule has been released, and odds are already available for Week 1 and several other high profile games.
The Seattle Seahawks and New England Patriots will meet in a Super Bowl rematch in the NFL’s season opener on Wednesday, Sept. 9. The defending champion Seahawks opened as 3.5-point home favorites.
The international series gets going Thursday, Sept. 10 with an NFC West matchup between the Los Angeles Rams — the current favorite to win the Super Bowl — and rival San Francisco 49ers in Melbourne, Australia.
The largest spread of Week 1 belongs to the Los Angeles Chargers, who are favored by 11.5 points over the Arizona Cardinals. The Chargers are the only double-digit favorite. Nine games have spreads of a field goal or less.
The highest points total in Week 1 is the Tampa Bay Buccaneers-Cincinnati Bengals matchup (50.5).
Here's a look at the early odds for every Week 1 game, as well as other highlights on the schedule that already have spreads.
Odds by DraftKings Sportsbook
and subject to change.
Wednesday, Sept. 9
New England Patriots at Seattle Seahawks (-3.5)
8:20 p.m. ET on NBC
Moneyline: Seahawks -192, Patriots +160
Total: 44.5 points
Thursday, Sept. 10
San Francisco 49ers vs. Los Angeles Rams (-2.5)
Melbourne Cricket Ground, Melbourne, Australia
8:35 p.m. ET on Netflix
Moneyline: Rams -148, 49ers +124
Total: 48.5 points
Sunday, Sept. 13
Chicago Bears (-2.5) at Carolina Panthers
1 p.m. ET on FOX
Moneyline: Bears -135, Panthers +114
Total: 44.5 points
Tampa Bay Buccaneers at Cincinnati Bengals (3.5)
1 p.m. ET on FOX
Moneyline: Bengals -198, Buccaneers +164
Total: 50.5 points
Check out all 32 teams’ Super Bowl odds, win total projections and more.
Baltimore Ravens (-3.5) at Indianapolis Colts
1 p.m. ET on CBS
Moneyline: Ravens -185, Colts +154
Total: 49.5 points
Buffalo Bills (-1.5) at Houston Texans
1 p.m. ET on CBS
Moneyline: Bills -112, Texans -108
Total: 45.5 points
New Orleans Saints at Detroit Lions (-7)
1 p.m. ET on FOX
Moneyline: Lions -325, Saints +260
Total: 48.5 points
New York Jets at Tennessee Titans (-3)
1 p.m. ET on CBS
Moneyline: Titans -170, Jets +142
Total: 39.5points
Atlanta Falcons at Pittsburgh Steelers (-3)
1 p.m. ET on FOX
Moneyline: Steelers -175, Falcons +145
Total: 42.5 points
Cleveland Browns at Jacksonville Jaguars (-7)
1 p.m. ET on CBS
Moneyline: Jaguars -290, Browns +235
Total: 40.5 points
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Arizona Cardinals at Los Angeles Chargers (-11.5)
4:25 p.m. ET on CBS
Moneyline: Chargers -625, Cardinals +455
Total: 45.5 points
Green Bay Packers (-1.5) at Minnesota Vikings
4:25 p.m. ET on CBS
Moneyline: Packers -125, Vikings +105
Total: 44.5 points
Miami Dolphins at Las Vegas Raiders (-3)
4:25 p.m. ET on FOX
Moneyline: Raiders -175, Dolphins +145
Total: 41.5 points
Washington Commanders at Philadelphia Eagles (-5.5)
4:25 p.m. ET on FOX
Moneyline: Eagles -238, Commanders +195
Total: 46.5 points
Dallas Cowboys (-1.5) at New York Giants
8:20 p.m. ET on NBC
Moneyline: Cowboys -130, Giants +110
Total: 47.5 points
Monday, Sept. 14
Denver Broncos at Kansas City Chiefs (-2.5)
8:15 p.m. ET on ESPN/ABC
Moneyline: Chiefs -155, Broncos +130
Total: 42.5 points
What Troy Aikman expects from Broncos-Chiefs looking ahead to Week 1
Mike Greenberg and Troy Aikman weigh in on Broncos-Chiefs kicking of Monday Night Football for Week 1.
Other highlighted games with odds available
"Thursday Night Football"
Sept. 17: Detroit Lions at Buffalo Bills (-3, 52.5), 8:15 p.m. ET (Prime Video)
(First game at the new Highmark Stadium)
Thanksgiving Eve
Green Bay Packers at Los Angeles Rams (-3.5, 49.5), 8 p.m. ET (Netflix)
Thanksgiving Day
Chicago Bears a Detroit Lions (-2.5, 51.5), 1 p.m. ET (CBS)
Philadelphia Eagles (-1.5, 49.5) at Dallas Cowboys, 4:30 p.m. ET (FOX)
Kansas City Chiefs at Buffalo Bills (-2.5, 49.5), 8:20 p.m. ET (NBC)
Christmas Day
Green Bay Packers at Chicago Bears (-1.5, 47.5), 1 p.m. ET (Netflix)
Los Angeles Rams at Seattle Seahawks (-1.5, 47.5), 8:15 p.m. ET (FOX)
