Southampton are hoping for a sixth successive win in all competitions having reached the FA Cup semi-finals with a victory over Arsenal last weekend and won 5-1 at Wrexham on Tuesday to move into the Championship play-off places.
Derby have won as many games away as they have at home this season (9) but were beaten at Coventry on their last road trip.
Southampton have lost just one of their past 10 league games against Derby (W3 D6), going down 1-0 at home in February 2007.
This is Derby's first away league game against Southampton since February 2012, when they lost 4-0 under Nigel Clough.
Since Tonda Eckert's first game in charge of Southampton on 5 November, the Saints have picked up the most points (54) and scored the most goals (55) of any Championship side.
John Eustace has picked up 84 points in 55 Championship games with Derby County (W24 D12 L19), the fifth-most of any side since his first game in charge last February.
Finn Azaz has been involved in eight goals in his past 12 home league starts for Southampton (5 goals, 3 assists), including three in his last three (2 goals, 1 assist).
