Former Manchester City defender Nedum Onuoha thinks both his former club and Chelsea face too much of an uphill battle to progress in the Champions League.
Both face three-goal deficits going into home legs, with Onuoha stating: "While they will have the belief they can do it, I think the margins are far too big. So while the game is still on for all the English sides, the margin of error is tiny for some of them now."
Their defeats come during a week in which English sides have struggled in Europe, with no wins recorded across six ties.
BBC Sport's Phil McNulty said we have seen “24 hours in which the Premier League’s self-styled reputation as the best in the world suffered heavy damage”.
"The Premier League's power was supposedly emphasised by having six teams in the last 16 following the league stage, but this was something of a cold shower hosed on talk of its supremacy," McNulty wrote.
All six English teams have now been given a lower predicted chance of reaching the last eight by Opta than before the last-16 first legs.
Arsenal remain favourites to progress, while Liverpool stay second favourites despite trailing by a goal after the first leg.
