Manchester City and Real Madrid have become familiar foes in this competition – this was the 11th meeting between the sides in the past five seasons and the La Liga giants prevailed again after their play-off round win last season and quarter-final victory two years ago.
Supporters had built up a fervent atmosphere in anticipation of a memorable result, but City will be sick of the sight of Real in the Champions League, being knocked out by their opponents on five occasions now.
The damage on this occasion was done with a heavy defeat in Spain and City's exit from Europe means any faint hopes of claiming four trophies this season have officially extinguished.
The draw against West Ham at the weekend leaves City with a huge task of reclaiming the Premier League title, trailing leaders Arsenal by nine points with eight games left to play, while they meet the Gunners in the Carabao Cup final on Sunday.
By the end of this week, City's campaign could be in ruins.
They host rivals Liverpool in the FA Cup quarter-finals next Sunday and if they are defeated at Wembley, that competition may turn out to be the only chance to claim silverware following last season’s trophyless showing.
With question marks remaining over Guardiola's future at City beyond the end of this summer, the manager has now failed to reach the quarter-finals of the Champions League for the second successive campaign – that has only happened once in his first 15 seasons as manager.
Before Silva's sending-off, the hosts will be aggrieved that an offside flag that went up in the build-up did not stand, with VAR intervening by saying Vinicius Junior was onside.
The winger's resulting shot was kept out by the City skipper's elbow and it was deemed as deliberate handball, reducing the home side to 10 men for almost 70 minutes of the game.
Even with 11 men on the pitch, City would have found it a struggle to turn the contest around, despite having a total of 21 shots, and both Jeremy Doku and Rayan Ait-Nouri having goals disallowed for offside.
Erling Haaland's goal proved merely to be a consolation but the Norwegian will be hoping the strike will help him back to form having scored only five times in his past 19 games in all competitions.
